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For the comparison of PLC with L-carnitine, the certainty of evidence was low because this included a single, very small, cross-over study

The product poses a threat to consumers because sibutramine is known to substantially increase blood pressure and/or pulse rate in some patients and may present a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmias, or stroke

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This allows it to pass through the blood-brain barrier making it the most bioavailable, and thus most easily absorbed, form