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Nano USM focusing technology was first seen in the 18-135mm f/3.5-5.6 IS USM launched in 2016 and made its L series debut in the RF 24-105mm f/4L IS USM

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By incorporating the antigen as an intrinsic structural element of the particle, this approach provides precise spatial control over antigen display, high stoichiometric uniformity, and superior particulate homogeneityadvantages that are difficult to achieve with post-assembly conjugation or non-covalent methods (Grgacic and Anderson, 2006)