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The compound has been investigated in adipocyte-research and metabolic-disease research contexts where elevated NNMT activity has been linked to insulin resistance and adipose-tissue dysfunction

Tirzepatide, a dual-agonist peptide, has shown significant results with a 22.5% weight loss over 72 weeks at a 15 mg dose (Jastreboff et al., NEJM), making it one of the most effective therapies for obesity

Combined NNMT inhibition and lean-diet substitution improves adiposity and body-composition endpoints in DIO mice

According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12)