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Consequently, this hormonal vacuum dysregulates hypothalamic pathways involving neuropeptides such as leptin and ghrelin, resulting in a persistent state of positive energy balance if caloric intake is not adjusted (24, 25)

Its relevance to women's health crystallised with the finding that MOTS-c levels decline with age and estrogen depletion correlating directly with reduced skeletal muscle insulin sensitivity and visceral adiposity in postmenopausal women

The pFeSAN is successfully demonstrated for the rapid colorimetric detection of glutathione with a low limit of detection (2.4 nM) and wide range (50 nM1 mM), and further developed as a real-time, facile, rapid (~6 min) and precise visualization analysis methodology of tumors via glutathione level, showing its potentials for diagnostic and clinic applications