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Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy, [see WARNINGS], reserve opioid analgesics, including hydrocodone bitartrate and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

That means 84% of what you're taking is essentially wasted

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and some sources note risk in conditions requiring immunosuppressive therapy (e.g., certain autoimmune diseases )