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Importantly, in contrast to the hypomorphic mutation described above, complete loss of TMEM106B on Grn / background leads to severe early motor dysfunction in mice

N.QianN.QiuB.HuF.ReznikE.et al

Once active GLP-1 is secreted, the enzyme DPP-4 quickly cleaves the majority of the hormone 10 and the remaining active GLP-1 enters circulation

Second, due to the limited size of our sample, statistical power was low and further analysis will be required to clarify these findings, and we cannot generalize the results for all children with ASD