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Neuroimaging (MRI of the spinal cord) may occasionally be warranted to exclude other pathology or to demonstrate the characteristic changes of subacute combined degeneration, though this is not routinely required for diagnosis

A reduction in G i2 protein, but not G o and G s , expression has been described in cabergoline-resistant with respect to sensitive prolactinomas ( i13 proteins has been reported in GH-secreting tumors ( Alterations in SSTRs signal transduction might be the cause of typical octreotide-resistance observed in acromegalic patients bearing germline mutations in aryl hydrocarbon receptor interacting protein (AIP) gene ( i signaling ( Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations ( Fougner et al