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Arendt-Nielsen L, Morlion B, Perrot S, Dahan A, Dickenson A, Kress HG, et al

Several of the DEGs were TF genes, including Klf4 and Klf5 , (Extended Data Fig

Qiao L, Liu X, He Y, Zhang J, Huang H, Bian W, Chilufya MM, Zhao Y, Han J (2021) Progress of signaling pathways, stress pathways and epigenetics in the pathogenesis of skeletal fluorosis

Unlike many drugs that simply block or force a pathway, these peptides were designed as bioregulators. They are analogs of molecules naturally found in the body that are based on an immune peptide called tuftsin, which is derived from a hormone fragment known as ACTH