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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing

Although these findings were initially observed in breast cancer, the lung microenvironment appears to serve as a key site of immune modulation, suggesting broader implications for lung cancer as both a primary and metastatic target