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The analgesic potential of glycosides derived from medicinal plants

We performed 13 C 2 -acetylcarnitine tracing and found that around 58% of cellular acetyl-CoA is derived from supplemented acetylcarnitine (Extended Data Fig

To consider the dose- and time-dependency of the model, we also tested a low dose of 10 ng h 1 for 9 days (low dose, longer time), 100 ng h 1 for 3 days (high dose, shorter time) and an acute treatment for 24 h (3 1.5 g, every 8 h)