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Recent genetic studies also suggest that defects of endolysosomal function could disrupt Syn homeostasis and mitochondrial function, causing neurotoxicity through unknown mechanisms (Kett and Dauer, 2016)

Although less compelling for humans, prematurely born infants are believed to lack the enzymes that convert cystathionine to cysteine, and may, therefore, become taurine-deficient if not breast-fed

The minimal clinically important difference threshold for weight loss in adults was considered as 5 % weight loss (Reference Shi, Wang and Hao21) , equal to 45 kg (Reference Shi, Wang and Hao22)