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Superoxide dismutase, CAT, and GSH-Px have been measured as antioxidants and MDA as an oxidative stress marker in numerous studies of psychiatric diseases (14, 15)

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DON exposure not only lead to ovarian arrested development, but also lead to reproductive hormones related genes such as Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR), follicle-stimulating hormone receptor (FSHR), cytochrome P450 family 11 subfamily a member 1 (CYP11A1), cytochrome P450 family 19 subfamily a member 1 (CYP19A1), 3b-Hydroxysteroid dehydrogenase type 1 (HSD3B1), and steroidogenic acute regulatory protein (StAR) and Follicle-Stimulating Hormone Subunit Beta (FSH) were inhibited in mRNA and protein level (Fig

Further complicating variant interpretation, a number of variants in the regulatory domain have previously been observed to render CBS biochemically hyperactive and yet paradoxically cause symptoms typical for CBS deficiency [15, 24,25,26, 63]