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215 Cyst(e)inase degrades extracellular cysteine and cystine and leads to decreased levels of intracellular cysteine and glutathione, which profoundly affects the redox potential of cancer cells 216 and counteracts the essential role of cysteine in cancer cells

Other symptoms may include: Glossitis (sore, red tongue) Mouth ulcers Visual disturbances (rare, due to optic neuropathy, requiring urgent assessment) Gastrointestinal symptoms such as diarrhoea or constipation It is crucial to recognise that neurological damage from B12 deficiency can become irreversible if left untreated for prolonged periods

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A.LinT.SaucierC.UrbeS.et al (2005)