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269 SierraA.BeccariS.Diaz-AparicioI.EncinasJ

Furthermore, several studies have shown that dysregulation of m6A regulatory factors plays a crucial role in leukemia, and alterations in the mRNAs they target (such as METTL14 and FTO) may be associated with the development of drug resistance [Yan et al., 2018

and RSL3, which targets GPX4) overcomes this limitation: the combination suppresses the mTOR4EBP1 axis to inhibit RCC cell activity and induce ferroptosis, offering a promising option for drug-resistant mRCC (260)