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doi: 10.1038/nrn1728 60

Caution is also advised if Botox is mixed with bupivacaine or other caine medications as this can be a fairly common allergy of some patients to these medications

These studies mainly focused on increased oxidative damage (Shao et al., 2006), impaired neuroprotective responses (Shimamura et al., 2004), worse blood brain barrier damage (Onyszchuk et al., 2008), and excessive pro-inflammatory responses in the thalamus (Sandhir et al., 2004), hippocampus (Sandhir et al., 2008), and cortex (Sandhir and Berman, 2010)