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It causes a little bit of stiffness

In 2015 IEEE 11th International Conference on e-Science , IEEE: 2015

NICE guidelines recommend a structured approach beginning with lifestyle modification and progressing to pharmacological interventions when appropriate

The starting dose for severe deficiency is typically 1500mcg (the full dose of the 1ml vial) given daily or on alternate days for 1 to 2 weeks, or until haematological remission is achieved