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[26,27] Whereas single-cells technologies are typically devoid of original tissue context, a recent work engaging multi-organ spatial transcriptome sequencing (stRNA-seq, spatial transcriptomics RNA sequencing) provided a panoramic multi-organ characterization of tissue senescence in aged mice and identify the aggregation of immunoglobulin G (IgG) as a marker and inducer of tissue senescence, unveiling a novel molecular target for senescence-targeted interventions

Give them at least 90 days, and then see how you feel

There are over 1,000-fold differential in EC50s between tumor and control non-tumorigenic cells (0.54 nM vs