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Interactions mediated primarily through the pre-NAC and NAC regions are more likely to inhibit aggregation, whereas interactions restricted to the terminiregions not part of the fibril coremay have little or no influence on Syn aggregation

Descamps-Latscha B, Witko-Sarsat V (2001) Importance of oxidatively modified proteins in chronic renal failure

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Conversely, metabolic dysregulation can contribute to the severity of multiple disease conditions including autoimmunity, alloimmunity, and cancer