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Mol Cell 61(2):210221

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Zhang et al., 2025), there is not an overwhelming amount of evidence showing that an aging-related decline of tissue NAD + levels facilitates aging and that preventing NAD + loss extends lifespan (Peluso et al., 2022), although nicotinamide mononucleotide (NMN) supplementation extended the median lifespan of female, but not male, mice by 8.5% ( + precursors nicotinamide, NMN, or nicotinamide riboside also improved some markers of health span in aged mice (Zhang et al., 2016)