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Another disruptive approach is to inject a hyperosmotic solution (one which has a higher solute concentration than the surrounding cells) into the carotid arteries to open the BBB for a time

Trust me, it's always on alert, squaring off against pesky free radicals and detoxifying the nasty stuff we encounter daily like chemicals, pollutants, and meds (WebMD)

Lam PL, Wong RS, Lam KH, Hung LK, Wong MM, Yung LH et al (2020) The role of reactive oxygen species in the biological activity of antimicrobial agents: an updated mini review

[33, 34] The most well-known is vitamin D deficiency, which can cause bone and joint pain, as well as a host of other symptoms