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Activation of the farnesoid X receptor (FXR), a ligandactivated nuclear hormone receptor that is a key regulator of bile acid homeostasis, has demonstrated clinical benefit in patients with PSC, as shown by the sustained reduction in serum alkaline phosphatase levels induced by multiple FXR agonists, including obeticholic acid in a phase 2 trial (NCT02177136)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Yadav AK, Harris-Kawano A, Saxena R, Jiang G, Ji J, Gao H, et al

(1988) Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States, Biol