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Therefore, testicular increases in IGF1 could mediate functional differentiation of testosterone-producing LCs in rhGH rats, and the increased circulating testosterone in rhGH rats may be due to the increased LH response in LCs by the testicular IGF1

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10.1038/s41467-022-35492-y 124 WangK.ZhangY.CaoY.ShiZ.LinY.ChenY.et al (2020)