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HPS2-THRIVE Collaborative Group

2022 Nov:112:109162

This was accompanied by a depletion of cellular NADPH and a reduction in the de novo synthesis of fatty acids and the amino acids serine and glycine

First-in-human (FIH) dosage prediction based on preclinical data is an important reference for phase I clinical design, which can effectively reduce the risk of human toxicity ( 2 Materials and methods 2.1 Chemicals, reagents, and materials Deg-AZM was provided by Nankai University (Tianjin, China)