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As for perimenopausal syndrome, osteoporosis is one of the most common disorders

At the transcriptional level, ketogenesis is regulated by many factors, with peroxisome proliferator-activated receptor alpha (PPAR) exerting a fundamental role as it orchestrates the transcription of genes involved in fatty acid transport, uptake and oxidation, as well as the synthesis and import of ketone bodies (Kersten et al., 2000

Furthermore, delivery methods with high bioavailability (such as intravenous injection) should be employed in clinical trials involving ALA to effectively avoid a reduction in research due to high loss of and inability to effectively deliver ALA

Notable examples are the glutamate-glutamine cycle between neurons and glia but also exchanges of glutamine between cancer-associated fibroblasts and cancer cells that support further tumour progression (Li et al, 2021