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Regarding manganese safety, it should be noted that the Mn 2+ content in the formulation is relatively low and predominantly exists in a coordinated state within MnUA rather than as free ions

Antonoff MB

Proc Natl Acad Sci USA 89:1173011734 Kim KS, Maio N, Singh A, Rouault TA (2018) Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients