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Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders

Glutamic acid/glutamate (Glu), glutamine (Gln), and alanine (Ala) are the most abundant amino acids in the body and an integral part of human cells and bacterial cell walls.11 They play unique roles in protein metabolism, cell signaling, harvesting energy, and nitrogen homeostasis

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The legal and ethical questions raised by the prospect of sharing organs without borders can be daunting to the extreme for some, but new allocation systems enabled by exciting new technology carry the promise of increasing access to this unique, lifesaving treatment, and a second transplant revolution