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Larger-sample studies are needed to verify these findings

F.KieperN.MaurerB.WaakJ.et al

In other instances, these ingested substances can stimulate melanin production, thus precipitating a color change

Classic example with conjugation occurring after introduction of a nucleophilic site (phenol) Kamata et al Drug Metabolism Disposition 2006 Many compounds or drugs contain functional groups that can be directly conjugated and thus do notrequire Phase I metabolism to create handles (nucleophiles) for conjugation.Ciprofloxacin Propranolol BilirubinDiflunisal Acetaminophen Thyroxine (T4)Q