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Glycation of -syn is believed to be an important factor that exacerbate neurotoxicity in PD patients ( The most common cause of ALS is believed to be due to missense mutations in SOD1 resulting in the disruption of redox homeostasis

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For example, in potassium chloride-induced hyperuricemic mice (172), arsenic-exposed mice (173, 174), and sodium fluoride-induced renal injury rat models (175), betaine exerts protective effects by regulating urate transporters, inhibiting oxidative stress, and modulating the Nrf-2/heme oxygenase-1 (HO-1) signaling axis (Figure 6B)

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