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The content of CoQ10 significantly increased in GCH1-overexpressing cells, possibly due to the abundant production of its biosynthetic precursor 4-OH-benzoate, which is dependent on BH4-mediated conversion of phenylalanine to tyrosine

We used two transgenes for neuronal RNAi enhancement, initially working with the P mec-18 sid-1 transgene, which enhances touch neuron RNAi and later pan-neuronal P rgef-1 sid-1 , which consistently supported strong knockdown (gift from the lab of Dr

Vitamin B12 Deficiency The prevalence of vitamin B12 deficiency among elderly Americans is thought to be about 20%

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