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These findings indicate that HIV-1 and CART induce lysosomal damage and predispose to FIN as elevated intracellular iron increases the odds of lipid peroxidation and ferroptotic cell death (Jiang et al., 2021)

Although these mechanistic studies elucidate the catalytic role of key active site residues, the basis of substrate specificity for the nucleophilic amino acid in the plant GS is less well understood