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And it was found for the first time that ISL could inhibit Annexin A2 expression both in vivo and in vitro , block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway and regulate the expression of -SMA by inhibiting the phosphorylation of STAT3 at the downstream signal to finally reverse HSCs activation and hepatic fibrosis (Liu et al., 2023)

Synaptogenic activity induces hippocampal spinogenesis and synaptogenesis in vitro and in vivo

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During I/R, mTOR1-mediated autophagy caused OTUD5 degradation and subsequent GPX4 decay, aggravating tubular cell ferroptosis and aggravating acute renal injury