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Endothelial dysfunction is defined as an impairment in the vascular endothelium, which plays a critical role in maintaining homeostasis, including regulation of normal smooth muscle relaxation

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Pestell School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia Konrad Pesudovs Department of Medicine, Endocrinology Unit, University of Padova, Padova, Italy Raffaele Pezzani Associazione Italiana Ricerca Oncologica di Base (AIROB), Padova, Italy Raffaele Pezzani Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China Michael R