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doi: 10.3389/fonc.2022.775649 Received 14 September 2021 Accepted 27 January 2022 Published 17 February 2022 Volume 12 - 2022 Edited by Bilian Jin, Dalian Medical University, China Reviewed by Tiziana Schioppa, University of Brescia, Italy

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Some patients may notice short-term improvement, while others may need a different treatment approach