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The nutritional supplement Protandim is especially promising as a NRF2 activator because it combines five known NRF2-inducing botanical extracts that act synergistically to induce NRF2 in vivo [38] and in vitro [9,44,51]

This research firmly establishes oxidative stress as a shared mechanistic basis for these conditions and underscores the critical need for targeted antioxidant therapies to protect cellular infrastructure