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In polarized epithelium, adaptor protein-1B (AP-1B) complex mediates clathrin-dependent polarized protein sorting (98)

[90] Aging and obesity [edit] NF-B is increasingly expressed with obesity and aging, [91] resulting in reduced levels of the anti-inflammatory, pro-autophagy, anti-insulin resistance protein sirtuin 1

Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12

You may even be able to use your Medicare benefits to cover some of the cost