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The strongest, proven benefits for skin come from topical application

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doi: 10.1080/19420862.2017.1304869 Summary Keywords immunogenicity, AMG 966, inflammatory bowel disease, anti-drug antibodies, TNF, TL1A, tolerance, immune complexes Citation Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF-S, Teixeira dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S and Mytych DT (2021) Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target

This proof-of-principle study shows selective and allele-sensitive CRISPRCas13d-mediated-targeting of mutant HTT, while retaining expression levels of normal HTT