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Curr Top Med Chem 4 : 283297

Targeted attenuation of elevated histone marks at SNCA alleviates -synuclein in Parkinsons disease

Islet amyloid polypeptide (IAPP) IAPP, a protein that is coexpressed and cosecreted with insulin by cells, forms membrane-permeable toxic oligomers and accumulates in the ER under continuous demand for insulin