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There were improvements in: stool frequency stool consistency intestinal permeability In a While this suggests L-glutamine may help manage IBS symptoms, the researchers note that they need more studies to establish a suitable dose

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500 mg daily is within standard supplementation ranges and generally considered safe for most healthy adults with normal liver function

Kee et al., 2023) and meta-analyses reinforces that genetic differences in drug-metabolizing enzymes directly influence plasma concentrations and clinical outcomes, with poor metabolizers tending toward higher exposure and potential toxicity, and ultrarapid metabolizers often demonstrating underexposure and poor therapeutic response