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This protective role is crucial in maintaining skin integrity and promoting a youthful appearance

Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression

Johnson JB, Summer W, Cutler RG, Martin B, Hyun D-H, Dixit VD, Pearson M, Nassar M, Telljohann R, Tellejohan R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP

N-Acetylcysteine, but not methionine or 2-oxothiazolidine-4- carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain