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A key mechanistic insight is that IL-6 upregulates hepcidin, which promotes transferrin degradation and amplifies the vicious cycle of iron overload (Burton et al., 2020) (Figure 3D)

237 In another clinical trial, 14 women with premature ovarian failure and 45 years of infertility underwent injection of donor umbilical cord-derived MSCs into an ovary, resulting in increased ovarian volume, blood flow, and function in some women three months later

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Outcomes were measured using PROMIS T-scoresvalidated, widely used patient-reported outcome instruments: Pain Intensity: 65.0 58.7 ( 6.3, p 98 percent purity via HPLC/MS, third-party testing for heavy metals and microbial contamination, and documentation of raw material endotoxin levels