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For instance, nanoparticles can be engineered to target specific cells or tissues, potentially increasing vaccine efficacy while minimizing adverse reactions

Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

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To trigger oxidative bursts, a flagellin fragment ( flg22 , AS-62633, Eurogentec, Cologne, Germany) was used as elicitor and added manually to a final concentration of 1 M in the respective wells