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doi: 10.1016/j.joca.2019.02.369 31 ValdianiATaleiDLattooSKOrtzRRasmussenSKBatleyJet al

Noradrenergic stimulation of the pineal gland occurs exclusively during darkness, triggering melatonin synthesis through a cascade involving arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase (HIOMT) [5]

Design was hyper-tracked occurring in approximately six months (including programming) compared to a normal schedule of eighteen months for this type of project.