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It had been shown that protein kinase R (PKR) was activated in the later stages of HSV-1 infection enhancing phosphorylation of eIF-2 (Chou et al., 1995) and inducing phosphorylation of endoplasmic reticulum resident kinase (pERK) (Cheng et al., 2005), thereby inhibiting protein synthesis (Poppers et al., 2000)

The selective reduction in selenoprotein mRNA and protein in macrophages from CD was observed in bulk culture while assessment of CD16 sub-populations was not conducted

Specifically, MS patients have increased plasmatic coagulation, reduced fibrinolysis, hyperreactive platelets, and impaired endothelial thrombo-resistance, increasing the risk for venous and arterial thrombosis (155, 158, 159)

PLGA = PLGA-PEG nanoparticles