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Subcutaneous injection (most peptides) Best sites: Abdomen (2+ inches from navel) Thighs (outer) Love handles Back of arms (harder to reach) Technique: Clean injection site with alcohol Pinch skin to create fold Insert needle at 45-90 degree angle Inject slowly (2-3 seconds) Remove needle, apply pressure Intramuscular injection (some peptides) Best sites: Glutes (upper outer quadrant) Thighs (vastus lateralis) Deltoids (shoulders) Technique: Clean injection site Insert needle at 90 degrees (deeper than SubQ) Aspirate (pull back plunger slightly to check for blood) Inject slowly Remove and apply pressure Rotation and site management Rotate injection sites: Never use same spot twice in one week Have 8-10 sites in rotation Track sites if injecting multiple times daily Avoid: Injecting into scar tissue Sites with visible inflammation Areas with lumps from previous injections Learn complete technique in our peptide injections guide

More patients receiving semaglutide discontinued treatment due to GI adverse reactions than patients receiving placebo during all clinical trials