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Mortality reached 684,996 deaths, with a cumulative risk of 1.49%, underscoring breast cancer as a critical public health challenge ( Table 1 ), but 24,047 deaths, translating to more than half of diagnosed patients succumbing to the disease, thus reflecting structural barriers such as poor access to mammographic screening, delayed presentation, and inadequate treatment infrastructure ( Table 1 Breast cancer incidence and mortality by world region (GLOBOCAN estimates) ( Mortality-to-incidence ratio (MIR) was calculated as (deaths incident cases) 100

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However, no genome-wide study has ever been carried out, in particular for any plant D-LDH

This dual functionality positions MYC as a central integrator of oncogenic, metabolic, and stress-adaptive pathways, with its impact on autophagy determined by the cellular context