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To validate that this synergistic interaction is indeed dependent on mut-p53 and SLC7A11 expression, we next demonstrated that these drug combinations were more effective in H1299 cells overexpressing mut-p53 compared to the p53 Null parental line (Fig

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The mTOR inhibitor everolimus also showed broad activity

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Patients on anticoagulants, anticonvulsants, or immunosuppressants should discuss this combination with their provider before starting

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