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J Biol Chem 284:921929 Casimir M, Lasorsa FM, Rubi B et al (2009) Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion

TB-500s primary mechanism involves the regulation of G-actin, the monomeric building block of actin filaments, by binding to it and controlling actin polymerization