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More serious side effects, although rare, can include allergic reactions, chest pain, severe dizziness, or numbness in extremities

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Treatment with vitamin B12 is thought to be safe, with long-term studies noting that there is no increased risk of mortality associated with high serum vitamin B12 concentrations[26]

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A deficiency in folic acid can cause a significant rise in homocysteine levels and cause a rise in oxidative damage that triggers melanocyte loss

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