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Animal models suggest that reductions in glutathione synthesis capacity in mid-life may precede later elevations in reactive oxygen species (ROS) and oxidative damage

Abbreviations BMP2: Bone morphogenic protein BC: Bone crest CEJ: Cementoenamel junction ELISA: Enzyme-linked immunosorbent assay Ep: Experimental periodontitis FBC: Furcal bone crest FR: Furcation roof GSH: Glutathione IL: Interleukin MDA: Malondialdehyde MDP: Microbial dental plaques MMP: Matrix metalloproteinases MSM: Methylsulfonylmethane PGE 2 : Prostaglandin E 2 RANKL: Receptor nuclear factor kappa B ligand OPG: Osteoprotegerin OSI: Oxidative stress index TAS: Total antioxidant status TNF-: Tumor necrosis factor-alpha TOS: Total oxidant status References Tonetti MS, Greenwell H, Kornman KS

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gasseri in healthy individuals, as they are responsible for inhibiting periodontal pathogens such as Porphyromonas gingivalis , Prevotella intermedia , and Aggregatibacter actinomycetemcomitans