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Furthermore, compared to rats exposed to normal gravity, tail-suspended rats exhibited a significant increase in apoptosis of IECs in the ileum, which was associated with upregulated expression of pro-apoptotic protein Bax and downregulated expression of anti-apoptotic protein Bcl-2 (Jin et al., 2018)

Elegant intraruminal device strategies comprise principles of expansion, osmotic release, and rolled-up polymers with drug embedded in a porous matrix